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Research Performance

In 2015 Asia's first clinical study of Embryonic stem cells, retinal cell therapy published.
The world's first the success rate of cloned stem cells dramatically increased.

Notice
Product Indication F&D Pre-Clinical Phase Note
Embryonic Stem Cells Pipelines
Retinal Pigment
Epithelial Cells
(MA09-hRPE)
Stargardt's Macular
Dystrophy (SMD)
Technology transfer & 
Partnership with US
Ocata Therapeutics, Inc.
Age-related Macular
Degeneration (AMD)
Myopic Macular
Degeneration (MMD)
Adult Stem Cells or Somatic Cells Pipelines
Placental Adherent
Stromal Cells (PLX-PAD)
Intermittent
Claudication (IC)
Technology transfer &
Partnership with Israel
Pluristem Therapeutics, Inc.
Umbilical Cord-derived
Mescenchymal
Stem Cells (CB-AC-01)
Acute Cerebral
Infarction
Disk Degeneration
Placenta-derived
Mescenchymal Stem
Cells (CB-AC-02)
Alzheimer's Disease
Global Cerebral Ischemia Investigator Initiated Trial
Traumatic Optic Nerve Investigator Initiated Trial
Adipose-derived
Mescenchymal
Stem Cells 
(CB-AC-03)
Articular Cartilage Injury Investigator Initiated Trial
Disk Degeneration Investigator Initiated Trial
Rheumatoid Arthritis
Diabetes mellitus
Neural Progenitor Cells Parkinson's Disease Investigator Initiated Trial
Immunocytes Recurrent Glioblastoma Investigator Initiated Trial
ovarian cancer Investigator Initiated Trial
liver cancer Investigator Initiated Trial
Dendritic Cells
Patents
Division Contents
Embryonic-derived stem cell Apply embryonic-derived stem cells for various indications by differentiating them to retinal pigment epithelium (RPE) Differentiation to various stem cells including embryonic-derived stem cells, culturing methods, and pharmaceutical composite materials.
Placenta-derived stem cell Separation, culture, and pharmaceutical usage of placenta-derived mesenchymal stem cells for various indications
Umbilical cord-derived stem cell Separation, culture, and pharmaceutical usage of umbilical cord-derived stem cells for various indications
Cord blood Agents including cord blood or cord blood-derived stem cells and its pharmaceutical usage for various indications
Fat-derived stem cell Separation, culture, and pharmaceutical usage of fat-derived stem cells for various indications
Testis-derived stem cell Testis-derived pluripotent stem cell manufacturing methods and its pharmaceutical usage for various indications
Induced pluripotent stem cell
(iPSC)
Induced pluripotent stem cell methods, associated pharmaceutical composite materials, and screening methods
Immunocyte Natural killer cell, dendritic cell, or T lymphocyte manufacturing methods and its pharmaceutical usage for various indications including cancer
Stem cell bank The stem cell bank operation system and its usage
Platform technology Drug screening using stem cells, customized diet suggestion system, and screening system for embryonic stem cell culture
Cosmetics Culture fluid originated from various tissues or cells, such as placenta-derived or stem cell-derived ingredients, and cosmetics composite materials including active ingredients
Cell extract Centrifugation bags, separation devices, etc. for extracting SVF (Stromal Vascular Fraction) or stem cells
Notice
Num. Title Author Journal names Date
1012 The Novel Peptide Vaccine GV1001 Protects Hearing in a Kanamycin-induced Ototoxicity Mouse Model KIM SY and 3 others Otology & Neurotology Jul-2018
1011 Sudden Sensorineural Hearing Loss Predicts Ischemic Stroke: a Longitudinal Follow-Up Study KIM SY and 3 others Otology & Neurotology Jul-2018
1010 Decision making processes of women who seek elective oocyte cryopreservation KIM RAN, YOON TK, KANG IS, KUNG MK, KIM YS, KIM MJ, LEE YB, and KIM JY Journal of Assisted Reproduction and Genetics Jul-2018
1009 Associations of miR‑146aC>G, miR‑149C>T, miR‑196a2C>T and miR‑499A>G polymorphisms with brain tumors LIM JJ, HAN IB, KWAK KB, KIM NK, CHO KK and 2 others Oncology Reports Jul-2018
1008 Comparison between the effects of deep and moderate neuromuscular blockade during transurethral resection of bladder tumor on endoscopic surgical condition and recovery profile: a prospective, randomized, and controlled trial KOO CH and 7 others World Journal of Urology Jul-2018
1007 Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes LEE BY and 3 others Journal of Ginseng Research Jul-2018
1006 Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study LEE BY and 4 others Nutrients Jun-2018
1005 Repurposing the Cord Blood Bank for Haplobanking of HLA‐Homozygous iPSCs and Their Usefulness to Multiple Populations Heo JY, SHIM SH, KANG MS, SONG JH and 14 others Stem Cells Jul-2018
1004 Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a Chung YW and 19 others Nature Communications Jul-2018
1003 Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment Hemant Kumar, HAN IB and 11 others Nano Letters Jul-2018
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Adipose Stem Cells

Adipose Stem Cells can be easily extracted with liposuction. They are ideal stem cells for the regenerative medicine due to the fact that a large amount of stem cells can be obtained from a relatively small amount of adipose tissues. They have been mainly only used for wrinkle improvement and cosmetic surgeries ; however, they are now widely applied to treat various diseases such as myocardial infarction, diabetes, liver ailment, ischemic peripheral circulatory disorders, urinary incontinence as numerous research outcomes proved that these cells have plenty of mesenchymal stem cells, which are helpful for cell restoration.

Patient - Harvest fat tissues - Adipose tissue(lipoaspirate) - RBC wash or lysis - Well mix with collagenase in shaking incubator - 1st centrifugation for SVF - 2nd centrifugation with N/S then pipette out N/S to wash out ollagenase, 2 times more Harvest thick pellet at bottom - Differentiate Adult Stem Cell - Fat, Bone, Muscle, Cartilage - Injection with fine tube as 1cc in every 1 minute after shaking well the syringe
Definition of SVF Therapy

Adipose tissues are major sources for stem cells.
SVF (Stromal Vascular Fraction) is defined as a therapy to inject stem cells intravenously, and the stem cells (2 to 5x106 units) are safely harvested with the medical instrument from adipose tissues obtained by conducting liposuction on the abdominal region.

Effects of SVF Therapy

The main purpose is the regeneration of stem cells.
In addition, it has a good effect on recovering chronic fatigue and preventing aging as it helps to form abundant growth factors as well as anti-inflammatory factors. Furthermore, there have been many patients who testified that they experienced the improvement of eyesight, erectile function, hair growth.

SVF Programs

Injection to Face To boost forming new blood vessels and collagens with the purpose to improve skin elasticity.
Intra-Venous Injection To improve clinical symptoms relevant to aging with the purpose to have an Anti-Aging effect.
Injection to Joint cartilage In order to reduce inflammation and pain, regenerate the articular cartilage.

Cord blood stem cells are used therapeutically in transplants to help cure, treat and repair damaged blood and immune systems.
Cord blood stem cells are being studied for potential use in regenerative medicine. CHA has been applying the stem cells to Cerebral Palsy patients since 2009 and developing pipeline for Stroke and Alzheimer's. Chaum provides opportunity to participate in the clinical trial for Cord Blood. We expect that this will help stimulate and guide the body's own repair system to heal damaged tissue and organs without any side effects.

Benefits of Cord Blood Clinical Trial

  • Cord Blood has abundant growth factors.
  • Cord Blood has excellent capabilities of differentiation
  • It's clearly proven that there is no adverse effect of transplanting cord blood.
  • CHA Health Systems Group's Cord Blood Bank has total 900 transplanting cases)

Cord Blood Stem Cell Collection & Transplant Process

Cord Blood Bank, ICORD

Cord blood transplant clinical status

It is ongoing to "Randomized, double-blind, placebo-controlled and pre-clinical studies for the potential efficacy and safety about improving clinical aging indicators by injection of Umbilical cord blood or plasma to adults in previous step of decrepitude" approved by the IRB.

Approximately 53% of the participants 84 (including during clinical studies with placebo) until now seemed to improve in the next part.