LIFE CENTER, CHAUM - The Power to Age Beautifully

Notice
Product	Indication	F&D	Pre-Clinical	Phase			Note
Product	Indication	F&D	Pre-Clinical	Ⅰ	Ⅱ	Ⅲ	Note
Embryonic Stem Cells Pipelines
Retinal Pigment Epithelial Cells (MA09-hRPE)	Stargardt's Macular Dystrophy (SMD)						Technology transfer & Partnership with US Ocata Therapeutics, Inc.
	Age-related Macular Degeneration (AMD)
	Myopic Macular Degeneration (MMD)
Adult Stem Cells or Somatic Cells Pipelines
Placental Adherent Stromal Cells (PLX-PAD)	Intermittent Claudication (IC)						Technology transfer & Partnership with Israel Pluristem Therapeutics, Inc.
Umbilical Cord-derived Mescenchymal Stem Cells (CB-AC-01)	Acute Cerebral Infarction
Umbilical Cord-derived Mescenchymal Stem Cells (CB-AC-01)	Disk Degeneration
Placenta-derived Mescenchymal Stem Cells (CB-AC-02)	Alzheimer's Disease
	Global Cerebral Ischemia						Investigator Initiated Trial
	Traumatic Optic Nerve						Investigator Initiated Trial
Adipose-derived Mescenchymal Stem Cells (CB-AC-03)	Articular Cartilage Injury						Investigator Initiated Trial
	Disk Degeneration						Investigator Initiated Trial
	Rheumatoid Arthritis
	Diabetes mellitus
Neural Progenitor Cells	Parkinson's Disease						Investigator Initiated Trial
Immunocytes	Recurrent Glioblastoma						Investigator Initiated Trial
	ovarian cancer						Investigator Initiated Trial
	liver cancer						Investigator Initiated Trial
	Dendritic Cells

Patents
Division	Contents
Embryonic-derived stem cell	Apply embryonic-derived stem cells for various indications by differentiating them to retinal pigment epithelium (RPE) Differentiation to various stem cells including embryonic-derived stem cells, culturing methods, and pharmaceutical composite materials.
Placenta-derived stem cell	Separation, culture, and pharmaceutical usage of placenta-derived mesenchymal stem cells for various indications
Umbilical cord-derived stem cell	Separation, culture, and pharmaceutical usage of umbilical cord-derived stem cells for various indications
Cord blood	Agents including cord blood or cord blood-derived stem cells and its pharmaceutical usage for various indications
Fat-derived stem cell	Separation, culture, and pharmaceutical usage of fat-derived stem cells for various indications
Testis-derived stem cell	Testis-derived pluripotent stem cell manufacturing methods and its pharmaceutical usage for various indications
Induced pluripotent stem cell (iPSC)	Induced pluripotent stem cell methods, associated pharmaceutical composite materials, and screening methods
Immunocyte	Natural killer cell, dendritic cell, or T lymphocyte manufacturing methods and its pharmaceutical usage for various indications including cancer
Stem cell bank	The stem cell bank operation system and its usage
Platform technology	Drug screening using stem cells, customized diet suggestion system, and screening system for embryonic stem cell culture
Cosmetics	Culture fluid originated from various tissues or cells, such as placenta-derived or stem cell-derived ingredients, and cosmetics composite materials including active ingredients
Cell extract	Centrifugation bags, separation devices, etc. for extracting SVF (Stromal Vascular Fraction) or stem cells

Notice
Num.	Title	Author	Journal names	Date
1080	Evaluation of valve function in antireflux biliary metal stents	KWON CI, KHO KH and 6 others	BMC Gastroenterology	Oct-2018
1079	Differential sonographic features of the extensor pollicis longus tendon rupture and other finger tendons rupture in the setting of hand and wrist trauma	LEE SM, HA DH, HAN SH	PLoS One	Oct-2018
1078	The predictors for the non-compliance to follow-up among very low birth weight infants in the Korean neonatal network	KIM NH and 7 others	PLoS One	Oct-2018
1077	Effects of school time on sleep duration and sleepiness in adolescents	LEE SK, CHAE KY	PLoS One	Sep-2018
1076	Immunomodulatory Effects of Placenta-derived Mesenchymal Stem Cells on T Cells by Regulation of FoxP3 Expression	KIM KJ and 6 others	International Journal of Stem Cells	Oct-2018
1075	Interarm Blood Pressure Difference is Associated with Early Neurological Deterioration, Poor Short-Term Functional Outcome, and Mortality in Noncardioembolic Stroke Patients	KIM JK and 4 others	Journal of Clinical Neurology	Sep-2018
1074	Relationship Between Anemia and the Risk of Sudden Cardiac Arrest　― A Nationwide Cohort Study in South Korea	YANG PS, SUNG JH and 6 others	Circulation Journal	Sep-2018
1073	A simple clinical risk score (C2HEST) for predicting incident atrial fibrillation in Asian subjects: Derivation in 471,446 Chinese subjects, with internal validation and external application in 451,199 Korean subjects	YANG PS and 8 others	Chest	Oct-2018
1072	Differential responses of endothelial integrity upon the intake of microencapsulated garlic, tomato extract or a mixture: a single-intake, randomized, double-blind, placebo-controlled crossover trial	LEE JH and 6 others	Food & function	Oct-2018
1071	Incidence, inhospital mortality, and readmission among patients with alcoholic hepatitis in Korea: A nationwide study	CHO YR	Journal of gastroenterology and hepatology	Oct-2018

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SVF Procedure
Cord Blood Clinical Trial

Adipose Stem Cells

Adipose stem cells are ideal for regenerative medicine due to the large amount that liposuction can easily obtain from a relatively small amount of adipose tissue. Up until now Adipose stem cells have primarily been used for wrinkle improvement and cosmetic surgeries. However, recent research has found that Adipose stem cells contain a high amount of mesenchymal stem cells, which can be used in cell restoration. Adipose stem cells are now being used to treat various diseases such as myocardial infarction, diabetes, liver ailments, ischemic peripheral circulatory disorders, and urinary incontinence.

Patient - Harvest fat tissues - Adipose tissue(lipoaspirate) - RBC wash or lysis - Well mix with collagenase in shaking incubator - 1st centrifugation for SVF - 2nd centrifugation with N/S then pipette out N/S to wash out ollagenase, 2 times more Harvest thick pellet at bottom - Differentiate Adult Stem Cell - Fat, Bone, Muscle, Cartilage - Injection with fine tube as 1cc in every 1 minute after shaking well the syringe

Definition of SVF Therapy

Adipose tissues are major sources of stem cells.
SVF (Stromal Vascular Fraction) is defined as a therapy in which stem cells are injected intravenously. The stem cells (2 to 5x106 units) are safely harvested from adipose tissues obtained via liposuction on the abdominal region.

Effects of SVF Therapy

The main purpose of SVF therapy is the regeneration of stem cells.
Additionally, it is effective in treating chronic fatigue and preventing aging as it helps to aid in the formation of growth factors and anti-inflammatory factors. Furthermore, there have been many patients who reported improved eyesight, male performance, and hair growth.

SVF Programs


Facial Injection	Improve skin elasticity through the formation of new blood vessels and fresh collagens.
Intra-Venous Injection	Achieve an Anti-Aging effect by treating the clinical symptoms related to aging.
Joint Cartilage Injection	Reduce joint inflammation and pain through the regeneration of articular cartilage.

Cord blood stem cells are used therapeutically in transplants to help cure, treat and repair damaged blood and immune systems.
Cord blood stem cells are being studied for potential use in regenerative medicine. CHA has been applying the stem cells to Cerebral Palsy patients since 2009 and developing pipeline for Stroke and Alzheimer's. Chaum provides opportunity to participate in the clinical trial for Cord Blood. We expect that this will help stimulate and guide the body's own repair system to heal damaged tissue and organs without any side effects.

Benefits of Cord Blood Clinical Trial

Cord Blood has abundant growth factors.
Cord Blood has excellent capabilities of differentiation
It's clearly proven that there is no adverse effect of transplanting cord blood.
CHA Health Systems Group's Cord Blood Bank has total 900 transplanting cases)

Cord Blood Stem Cell Collection & Transplant Process

Cord blood transplant clinical status

It is ongoing to "Randomized, double-blind, placebo-controlled and pre-clinical studies for the potential efficacy and safety about improving clinical aging indicators by injection of Umbilical cord blood or plasma to adults in previous step of decrepitude" approved by the IRB.

Approximately 53% of the participants 84 (including during clinical studies with placebo) until now seemed to improve in the next part.

Research Performance

Adipose Stem Cells

SVF Programs

Benefits of Cord Blood Clinical Trial

Cord Blood Stem Cell Collection & Transplant Process

Cord blood transplant clinical status