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Home Bio Technology

Research Performance

In 2015 Asia's first clinical study of Embryonic stem cells, retinal cell therapy published.
The world's first the success rate of cloned stem cells dramatically increased.

Notice
Product Indication F&D Pre-Clinical Phase Note
Ⅰ Ⅱ Ⅲ
Embryonic Stem Cells Pipelines
Retinal Pigment
Epithelial Cells
(MA09-hRPE)		 Stargardt's Macular
Dystrophy (SMD)		 Technology transfer & 
Partnership with US
Ocata Therapeutics, Inc.
Age-related Macular
Degeneration (AMD)
Myopic Macular
Degeneration (MMD)
Adult Stem Cells or Somatic Cells Pipelines
Placental Adherent
Stromal Cells (PLX-PAD)		 Intermittent
Claudication (IC) 		Technology transfer &
Partnership with Israel
Pluristem Therapeutics, Inc.
Umbilical Cord-derived
Mescenchymal
Stem Cells (CB-AC-01)		 Acute Cerebral
Infarction
Disk Degeneration
Placenta-derived
Mescenchymal Stem
Cells (CB-AC-02)		 Alzheimer's Disease
Global Cerebral Ischemia Investigator Initiated Trial
Traumatic Optic Nerve Investigator Initiated Trial
Adipose-derived
Mescenchymal
Stem Cells 
(CB-AC-03)		 Articular Cartilage Injury Investigator Initiated Trial
Disk Degeneration Investigator Initiated Trial
Rheumatoid Arthritis
Diabetes mellitus
Neural Progenitor Cells Parkinson's Disease Investigator Initiated Trial
Immunocytes Recurrent Glioblastoma Investigator Initiated Trial
ovarian cancer Investigator Initiated Trial
liver cancer Investigator Initiated Trial
Dendritic Cells
Patents
Division Contents
Embryonic-derived stem cell Apply embryonic-derived stem cells for various indications by differentiating them to retinal pigment epithelium (RPE) Differentiation to various stem cells including embryonic-derived stem cells, culturing methods, and pharmaceutical composite materials.
Placenta-derived stem cell Separation, culture, and pharmaceutical usage of placenta-derived mesenchymal stem cells for various indications
Umbilical cord-derived stem cell Separation, culture, and pharmaceutical usage of umbilical cord-derived stem cells for various indications
Cord blood Agents including cord blood or cord blood-derived stem cells and its pharmaceutical usage for various indications
Fat-derived stem cell Separation, culture, and pharmaceutical usage of fat-derived stem cells for various indications
Testis-derived stem cell Testis-derived pluripotent stem cell manufacturing methods and its pharmaceutical usage for various indications
Induced pluripotent stem cell
(iPSC)		 Induced pluripotent stem cell methods, associated pharmaceutical composite materials, and screening methods
Immunocyte Natural killer cell, dendritic cell, or T lymphocyte manufacturing methods and its pharmaceutical usage for various indications including cancer
Stem cell bank The stem cell bank operation system and its usage
Platform technology Drug screening using stem cells, customized diet suggestion system, and screening system for embryonic stem cell culture
Cosmetics Culture fluid originated from various tissues or cells, such as placenta-derived or stem cell-derived ingredients, and cosmetics composite materials including active ingredients
Cell extract Centrifugation bags, separation devices, etc. for extracting SVF (Stromal Vascular Fraction) or stem cells
Notice
Num. Title Author Journal names Date
751 Sputum bacteriology and clinical response to antibiotics in moderate exacerbation of chronic obstructive pulmonary disease Lee JH Clinical Respiratory Journal Aug-2017
750 Home remodeling and food allergy interact synergistically to increase the risk of atopic dermatitis Lee KS, Lee SH, Lee SJ, Jee HM, Shin YH, Han MY, Jung YH BioMed Research International Aug-2017
749 microRNA-133a attenuates cardiomyocyte hypertrophy by targeting PKCδ and Gq Moon JY Molecular and Cellular Biochemistry Aug-2017
748 Discrepancy between self-assessed hearing status and measured audiometric evaluation Kim SY PLoS One. Aug-2017
747 Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice Ko EJ, Seo YJ, Choi JA, Kim KJ, Lee BY Molecules Aug-2017
746 An improvement of miRNA extraction efficiency in human plasma Ban EM Analytical and Bioanalytical Chemistry Aug-2017
745 Osteogenic potential of tauroursodeoxycholic acid (TUDCA) as an alternative to rhBMP-2 in a mouse spinal fusion model Kim BJ, YoshieAraai, Park EM, Park JH, Alvin Bacero bello, Han IB, Lee SH Tissue Engineering Part A Aug-2017
744 Risk Factors for a False-Negative result of Sentinel Node Biopsy in Patients with Clinically Node negative Breast Cancer Lee SA CANCER RESEARCH AND TREATMENT Jul-2017
743 Small airway bronchodilator response to different doses of salbutamol in 7-year-old children Yun DK, Jee HM, Ha EK, Lee SJ, Jung YH, Lee KS, Han MY Respiratory Research Aug-2017
742 Impact of left main coronary artery disease on long-term mortality in patients undergoing drug-eluting stent implantation Kang SH Clinical Research in Cardiology Aug-2017
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Adipose Stem Cells

Adipose Stem Cells can be easily extracted with liposuction. They are ideal stem cells for the regenerative medicine due to the fact that a large amount of stem cells can be obtained from a relatively small amount of adipose tissues. They have been mainly only used for wrinkle improvement and cosmetic surgeries ; however, they are now widely applied to treat various diseases such as myocardial infarction, diabetes, liver ailment, ischemic peripheral circulatory disorders, urinary incontinence as numerous research outcomes proved that these cells have plenty of mesenchymal stem cells, which are helpful for cell restoration.

Patient - Harvest fat tissues - Adipose tissue(lipoaspirate) - RBC wash or lysis - Well mix with collagenase in shaking incubator - 1st centrifugation for SVF - 2nd centrifugation with N/S then pipette out N/S to wash out ollagenase, 2 times more Harvest thick pellet at bottom - Differentiate Adult Stem Cell - Fat, Bone, Muscle, Cartilage - Injection with fine tube as 1cc in every 1 minute after shaking well the syringe
Definition of SVF Therapy

Adipose tissues are major sources for stem cells.
SVF (Stromal Vascular Fraction) is defined as a therapy to inject stem cells intravenously, and the stem cells (2 to 5x106 units) are safely harvested with the medical instrument from adipose tissues obtained by conducting liposuction on the abdominal region.

Effects of SVF Therapy

The main purpose is the regeneration of stem cells.
In addition, it has a good effect on recovering chronic fatigue and preventing aging as it helps to form abundant growth factors as well as anti-inflammatory factors. Furthermore, there have been many patients who testified that they experienced the improvement of eyesight, erectile function, hair growth.

SVF Programs

Injection to Face To boost forming new blood vessels and collagens with the purpose to improve skin elasticity.
Intra-Venous Injection To improve clinical symptoms relevant to aging with the purpose to have an Anti-Aging effect.
Injection to Joint cartilage In order to reduce inflammation and pain, regenerate the articular cartilage.

Cord blood stem cells are used therapeutically in transplants to help cure, treat and repair damaged blood and immune systems.
Cord blood stem cells are being studied for potential use in regenerative medicine. CHA has been applying the stem cells to Cerebral Palsy patients since 2009 and developing pipeline for Stroke and Alzheimer's. Chaum provides opportunity to participate in the clinical trial for Cord Blood. We expect that this will help stimulate and guide the body's own repair system to heal damaged tissue and organs without any side effects.

Benefits of Cord Blood Clinical Trial

  • Cord Blood has abundant growth factors.
  • Cord Blood has excellent capabilities of differentiation
  • It's clearly proven that there is no adverse effect of transplanting cord blood.
  • CHA Health Systems Group's Cord Blood Bank has total 900 transplanting cases)

Cord Blood Stem Cell Collection & Transplant Process

Cord Blood Bank, ICORD

Cord blood transplant clinical status

It is ongoing to "Randomized, double-blind, placebo-controlled and pre-clinical studies for the potential efficacy and safety about improving clinical aging indicators by injection of Umbilical cord blood or plasma to adults in previous step of decrepitude" approved by the IRB.

Approximately 53% of the participants 84 (including during clinical studies with placebo) until now seemed to improve in the next part.