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Stem Cell Technology

There have been various ongoing studies on stem-cell treatments for intractable and chronic diseases.

Definition of Stem Cell

Stem cell, as a primitive stage cell, can be differentiate into every cell or tissue in our body. Stem cells are undifferentiated biological cells that obtain specific functions and shapes through differentiation. They are capable of renewing themselves and differentiating into a number of cell types. Studies on stem cell therapy for treating incurable or chronic diseases are underway from around the world, and some stem cell therapies have been already approved to treat some of the incurable diseases.

Kinds of stem cells

Kinds of stem cells
Pluripotent ESC ESC(Embryonic stem cell) Embryonic stem cell, derived from an embryo, is a cell that can be differentiated into all types of cells. Research has been conducted to use such properties of embryonic stem cells to regenerate the tissue damaged from injuries or diseases by differentiating them into specific tissue. However, such research has faced an ethical issue as it uses an embryo. ESC, SCNT clinical studies about Retinal Pigment Epithelial Cells (hES-RPE) are on going (other)
  • SMD (Stargardt's Macular Dystrophy)
  • AMD (Age-related Macular Degeneration)
  • MMD (Myopic Macular Degeneration)
SCNT-ESC SCNT-ESC(Somatic-cell nuclear transfer) It is possible that somatic cell nuclear are reprogrammed in the embryonic state because the egg cells play a role in controlling the expression of specific genes of somatic-cell nuclear and reprogramming the embryonic-specific genes in the course of transferring somatic cell nuclear. Selected as a research authorized institution for Cloned embryonic stem cells
  • From April 2009 to April 2012 (3 years)
  • Having know-how in a variety of conditions related to nuclear transfer and the blastocyst formation
iPS Cell iPS Cell(Induced pluripotent stem cell) Induced pluripotent stem cells can be directly generated from adult cells which are not originally pluripotent, Pluripotent stem cells like embryonic stem cells are created either by introducing dopamine-producing four specific genes to the somatic cells or by reinjecting the reprogramming-inducing protein extracted from the cells with four specific genes. The World's first, Adult cloned embryonic stem cells established
  • Dr. Dongryul Lee, Dr. Yeonggi Jeong (2014.04.21)
  • Conducted in the United States for using frech eggs
Kinds of stem cells
Multipotent Adult
Stem Cell Adult Stem Cell Adult stem cell that can be found in various tissues is easily and safely taken from peripheral blood, fat, bone marrow, placenta and umbilical cord. It has been already differentiated to perform a specific function, so each adult stem cell can be used for different diseases depending on the level of potential differentiation.
Adipose Adipose(Adipose-derived stem cells) Adipose-derived stem cells can be easily earned from liposuction, these types of cells are very ideal cells in terms of the regenerative medicine because a large amount of cells can be gained from a small amount of adipose tissues. Preclinical stage (self)
  • CD (Cartilage defect), DD (Disk Degeneration)
  • Fat transplantation (face, back of the hand on the chest)
  • Reproduced knee cartilage
Bone
Marrow Bone Marrow Bone Marrow Cells are capable of forming pancreatic Islets, precursor cells ; a study shows that these cells help to cure diabetes by stimulating insulin secretion
Placenta Placenta Placenta contains plenty of hematopoietic stem cells generating blood as well as mesenchymal stem cells which can be differentiated into muscles, nerves, bones, fat. Preclinical stage (other)
  • GCI (Global Cerebral Ischemia) Preclinical completed
  • AD (Alzheimer's disease) clinical studies ongoing
Cord Blood Cord Blood Cord Blood is blood derived from an umbilical cord, this has been used in the regenerative medicine as a material to create hematopoietic stem cells, and the blood also contains plenty of mesenchymal stem cells that enable to cure intractable diseases. Clinical progress (self/ other)
  • Cerebral Palsy Treatment (HIRA application of new medical technology advances)
  • ALS
  • Traumatic Brain Injury
Umbilical
Cord Umbilical Cord Umbilical Cord contains abundant mesenchymal stem cells which can be differentiated into nerve cells, myocyte (muscles cells), bone cells, cartilage cells, therefore, it can be used to cure intractable diseases like liver ailment, bone diseases, diabetes, muscular disease, nerve disorder.
Commercial clinical progress (other)
  • ST (stroke)
Preclinical stage (other)
  • CD (Cartilage defect), DD (Disk Degeneration)
Fetal
Stem Cell
Neural
Precursor Cell Neural Precursor Cell NSC; Neural stem cells in an adult brain form neural progenitor cells which are immediately split, these neural progenitor cells are differentiated into nerve cells, stellate cells, oligodendrocyte to play a role in curing injury and diseases as well as the cognitive function.
Clinical progress (other)
  • PD (Parkinson's Disease)